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2 patients had neurological symptoms and signs,with evidence of central- nervous-system demyelination,6 weeks after administration of recombinant hepatitis B vaccine.1 had known multiple sclerosis but the other had no history of neurological disease;both had HLA haplotypes DR2 and B7,which are associated with multiple sclerosis.A causal link between vaccination and demyelination cannot be established from these 2 case-reports,but the time interval would fit a proposed immunological mechanism. |
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